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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: Perineural Dexmedetomidine Attenuates Inflammation in Rat Sciatic Nerve via the NF-κB Pathway
doi: 10.3390/ijms15034049
Figure Lengend Snippet: Perineural administration of 20 μg/kg dexmedetomidine decreased the translocation to the nucleus and transcriptional binding activity of NF-κB. ( A ) Western blot showed that 20 μg/kg dexmedetomidine decreased NF-κB translocation into the nucleus; ( B ) Dexmedetomidine (20 μg/kg) decreased the nuclear NF-κB protein level; ( C ) Dexmedetomidine (20 μg/kg) did not alter the total NF-κB protein level; ( D ) EMSA showed that 20 μg/kg dexmedetomidine decreased the transcriptional binding activity of NF-κB (lane 3); PDTC also decreased NF-κB transcriptional binding activity (lane 5). NF-κB, nuclear factor-kappa B; PDTC, pyrrolidine dithiocarbamate.
Article Snippet: An
Techniques: Translocation Assay, Binding Assay, Activity Assay, Western Blot